RAD140 (Testolone)

RAD 140, also known as Testolone, is an orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM)  that has the ability to increase lean muscle mass and reinforce the  effects of testosterone without the unwanted side effects of anabolic  steroids.

Early studies and user reviews have delivered better results than  steroid use with minimal side effects, making it one of the most  exciting and powerful SARMs to date. Read on for a comprehensive review  of everything you need to know about RAD 140, including benefits, side effects, studies and results for increasing muscle mass and preserving gains.

The androgen receptor (AR) primarily targets normal human sexual  development, but its activation by compounds (such as testosterone) also  effects bone, muscle, liver and the central nervous system.

The problem within the medical and bodybuilding communities is that  using testosterone to activate AR signaling for increased muscle and  bone development also affects the sex tissues, resulting in testicular  atrophy, enlarged clitoris in females and even risks of prostate cancer.  [1]

RAD140, a nonsteroidal selective androgen receptor modulator (SARM)  bypasses this issue. Due to the way RAD140 binds to the androgen  receptor, different cells respond by releasing different proteins, with  only some androgen receptors being activated throughout the body.

This stimulation results in androgen receptor activation in bone and  muscle cell, rather than raising liver enzymes or affecting sexual  tissue.

1. RAD140 helps increase muscle mass

The number one benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys, scientists observed an average weight gain of more than 10% in just 28 days. This was done using only RAD 140 and without any adverse side effects traditionally related to testosterone.

2. RAD140 may enhance speed, stamina and endurance during high-intensity workouts

Want to work out longer, harder and get better results every time you hit the gym? Reports of enhanced speed, stamina and endurance during workouts are common when supplementing with Testolone. Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.

3. RAD140 has a greater anabolic effect than testosterone

Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects.

RAD140 interacts with the hormonal receptors of muscle and bone tissue in the same ways as larger doses of testosterone, all without the estrogenic side effects caused by anabolic steroids.

Many users on forums also report greater anabolic effects than testosterone and is sometimes used as a PCT for steroid users to retain muscle mass between cycles.

4. RAD140 may reduce the side effects of testosterone

When taken in conjunction with anabolic steroids, initial studies indicated that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys.

Additionally, many anabolic steroid users report concerns for the health of their liver. However, during the 28-day trial these monkeys also showed minimal liver enzyme elevations on a dose 10x higher than the fully effective dose, even though weight was gained during a short timeframe (which can cause liver strain).

Our advice? With the results from RAD140 already proving better than anabolic steroid use, users may be better off forgetting testosterone altogether and sticking to SARMs.

5. Testolone does not appear to have the same side effects of anabolic steroids on reproductive organs

Initial studies on mice have found that low doses of RAD140 is all that’s needed to stimulate muscle growth without affecting the weight of the prostate.

This means that RAD140 has the ability to selectively stimulate muscle and bone growth while reducing the effects on sex tissue such as the prostate or clitoris. (So yes, this means RAD140 is safe for women)

6. RAD140 may aid weight loss by increasing fat loss

RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, in increase in the metabolism is seen, which results in easier weight loss.

Users also report increased muscle growth and decreased fat stores thanks to RAD140’s ability to increase stamina, endurance and speed during a interval training.

7. RAD140 is being trialed for the treatment of breast cancer

RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of Androgen Receptor (AR) and Estrogen Receptor Positive (ER+) breast cancer in postmenopausal women.

In vitro studies completed in 2017 showed that RAD140 inhibited the growth of AR/ER+ breast cancer cells. Results from these studies supported further investigation of RAD140 as a breast cancer treatment, and the first human clinical trials were brought forward .

8. RAD140 is indicated to be neuroprotective for brain health in neurodegenerative diseases

As testosterone levels in men decline, the risk of disease in androgen-responsive tissue (including the brain) increases, implicating the development of neurodegenerative diseases such as Alzheimer’s Disease.

However, treating AR diseases with testosterone may increase the risk of prostate cancer. Recent studies suggest that RAD140 may be as effective as testosterone in reducing cell death without side effects to the prostate.

As with most SARMs, studies show that RAD140 does not appear to have  any side effects common to steroidal compounds. Unlike testosterone,  RAD140 does not cause prostate enlargement or testicular shrinkage.

However, as it is still in early developmental stages, this does not mean that there are no long-term effects. Some user-reported side  effects include headaches or insomnia that disappear with correct  dosage.

Testolone studies are still being produced, but it has been known to have equal potency and effectiveness to that of LGD4033.

Studies on male primates suggest 20-30mg per day every 24-36 hours is  optimal for maximum skeletal hypertrophy, inline with anecdotal  testimonials from users. Safe durations for research have been tolerated  for up to 12 weeks, however, developing trials may indicate tolerance  for up to 24 weeks.

It is important to note that RAD140 systematically regulates the  neuroexcitatory amino acid Kainate which activates glutamate receptors  in the brain. Kainate acid’s role in neuronal cell death (specifically  in the hippocampus) has been shown to be a primary contributor to  Alzheimer’s disease. RAD140 has demonstrated positive results in the  prevention of Kainate acid production and medical based research  published by The Endocrine Society suggests RAD140 can improve brain health through neuroprotective properties in as little as 13 days (Jayaraman, 2014).

Although safe for women, lower doses ARE recommended. Females are advised to start at 5mg per day with an upper limit of no more than 10mg per day