GW 501516 (Cardarine)

GW 501516 (or Cardarine), is a research  chemical developed in the 1990s to prevent and cure tumor formation in  the colon, prostate, and breasts. Studies done in the early 2000s have  found that GW 501516 and other PPAR agonists have also been able to stop  metabolic disorders such as obesity and diabetes through specific gene  expressions.

As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it “the ultimate endurance enhancing supplement.”

Plus, Cardarine’s ability to burn off excess fatty tissue, enhance  recovery, and dramatically increase endurance has made this product a  staple in every athlete’s cycle and PCT. With no harmful side effects  found in the past 20 years, no wonder why GW 501516 has become a legend  in the world of sports and athleticism.

GW 501516 is is a PPARδ  agonist and NOT a SARM, but does work in very similar ways. In this  case, GW 501516 targets the androgen receptors that stimulate glucose  uptake and skeletal muscle tissue. Currently, it is being suggested as a  potential treatment for obesity by rapidly melting through through  what’s called “fatty acid oxidation“.

Also, Cardarine is said to increase HDL by an average of 79% (good  cholesterol) and decrease LDL (bad cholesterol) in current Phase II  trials.

These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1.

The benefits of Cardarine seem to be endless, both in medical science  and in the gym. Many studies have been done on GW 501516 showing  numerous positive effects during trial, despite minimum side effects.

That is part of the reason why Cardarine has recently become so popular.

Below are a list of the most powerful benefits that you could  experience while taking a cycle of GW 501516 (compiled from much  research and study)

GW 501516 is literally the best it gets when it comes to endurance, energy, stamina, and performance enhancement of any kind.

It is used by elite athletes for a reason, from cyclists to elite bodybuilders. In fact, WADA has even addded GW 501516 to their list of banned substances because of it’s competitive advantage.

You can expect insane levels of intensity in the gym, shorter  recovery times, and be able to bust through plateaus like never before.

Also, the energy you get from Cardarine is not experienced as jittery  or anxious. It’s not a stimulant, and you won’t crash hours later.

In fact, many users even report feeling an overall sense of well being and calmness.

Some of the other benefits include:

• Rapidly melts fat and NON catabolic.
• Provides noticeable results on the first dose.
• The ability to run for as long as 8-12+ weeks.
• Is versatile and can be stacked with anything.
• Can be used while cutting OR bulking.
• No side effects, liver toxicity, or suppression have been reported.
• No need for a PCT

THE PRIMARY ROLE is GW’s ability to rid the body of unwanted fatty  tissue and it has become almost LEGENDARY. The chemical compounds in  this particular PPAR agonist functions in differentiation of adipocytes.

Much like growth hormone, GW 501516 generates proinflammatory markers  in adipose tissue and decreasing the activity of genes involved in  lipogenesis. This means that the body is able to block fatty acid chains  from forming and being stored as fat.

 The 2015 study by Wei Chen, PhD and his colleges has also found that  dramatic increases in the PPAR gene in slow twitch muscle fibers  increases oxygen usage and greatly increases endurance. The enhanced  endurance was seen in lab mice with a normal oxygen supply and those  with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level. 

A study titled “A metabolomic study  of the PPARδ agonist GW501516 for enhancing running endurance in Kunming  mice” stated that BCAA were spared during trials of intense exercise  which allowed the mice to have a greater rate of recovery in muscle  tissue and neurotransmitters.

These rats had even lost weight while maintaining a high fat diet,  suggesting it could potentially prevent obesity and help manage weight  regardless of diet or lifestyle.

The study is quoted stating: “physiological and pathophysiological  functions of PPAR and generated novel strategies to treat metabolic  diseases”.

The activation of these particular genes in the body have been seen  to burn body fat at such an alarming rate that it is being coined “the cure to obesity”.

There were absolutely no adverse side effects detected in the last 20  years of study and it was extremely rare to see muscle wasting at any  point during the research.